Wir erlauben uns auf den Vortrag von Prof. Andreas A. Linninger
am IMKAI hinzuweisen:
VORTRAG
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Institut fuer Medizinische Kybernetik und Artificial Intelligence(IMKAI)
des Zentrums fuer Hirnforschung der Medizinischen Universitaet Wien
Freyung 6/2, A-1010 Wien
Tel.: +43-1-4277 631-01, Email:sec@ai.univie.ac.at
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Ass.Prof. Dr. Andreas A. Linninger,
University of Illinois, Chicago, IL
TRANSPORT PROCESSES IN THE BRAIN
Pertinent transport mechanisms of blood, cerebrospinal fluid or
large proteins (e.g. drugs) inside the human brain and the
central nervous system (CNS) are still poorly understood. The
aim of our interdisciplinary research is to quantify intracranial
transport and metabolic reaction phenomena. Our systems approach
admits only fundamental principles of fluid mechanics and
elasto-dynamics for relating the distensible vascular system to
the pulsatile CSF motion. The new model quantifies deformations of
the distensible blood vessels, brain tissue strains, pressure
gradients inside the brains gray and white and three-dimensional
CSF flow fields. We introduce a novel problem inversion technique
to determine transport or metabolic parameters from advanced
imaging data in vivo. The findings permit the optimal design of
drug delivery options for diseases of the central nervous system
and explain shortcomings in existing treatments. The examples taken
from biomedicine demonstrate the role of first principles
mathematical models as a versatile knowledge acquisition tool.
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Zeit: Montag, 19. Dezember 2005, 18:30 Uhr pktl.
Ort: Inst. f. Medizinische Kybernetik und Artificial Intelligence
d. Zentrums f. Hirnforschung der Med. Universitaet Wien,
Wien 1, Freyung 6, Stg.2 (Schottenhof), Tel. 4277-63101
www.ai.univie.ac.at/imkai